Vinod Khosla on AI, moonshots, and building enduring startups — all at TechCrunch Disrupt 2025

Vinod Khosla, the founder of Khosla Ventures, delivered a fireside chat at TechCrunch Disrupt 2025, sharing his insights on various topics. Key points: 1. AI: Khosla discussed the potential of AI technology and its transformative impact across industries, including healthcare and climate change. 2. Moonshots: He emphasized the importance of taking on ambitious, high-risk projects that have the potential to create significant change. 3. Enduring Startups: Khosla provided advice on how founders can build successful and long-lasting companies, particularly in turbulent economic times. 4. Candid Perspective: The veteran investor offered blunt, big-picture advice, drawing from his extensive experience in the tech industry. The session provided attendees with an opportunity to gain valuable insights from one of the most influential figures in the technology sector, covering a range of topics that are crucial for the future of startups and innovation.