Sports9/27/2025•CBS Sports
Where to watch 49ers vs. Jaguars: TV channel, live stream, prediction, pick, odds, spread
The San Francisco 49ers, who have been dealing with multiple injuries, will face the Jacksonville Jaguars in an NFL matchup. The 49ers, currently undefeated, will aim to maintain their winning streak against the Jaguars. The game will be broadcast on television and available for live streaming. Odds and point spreads have been set, with the 49ers favored to win. Analysts have provided their predictions and picks for the outcome of the game.
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