College football picks: Predictions against the spread, odds, betting lines for top 25 games in Week 6

The article provides predictions and analysis for the top 25 college football games in Week 6 of the 2025 season. It covers the matchups, point spreads, odds, and betting lines for these highly anticipated matchups. The article highlights several key games, including a top-10 showdown between No. 4 USC and No. 8 Oregon, as well as a clash between No. 2 Alabama and No. 15 Texas A&M. It also discusses the potential impact of these games on the college football landscape and the race for the playoffs. The article draws upon expert analysis and statistical data to provide readers with a comprehensive preview of the upcoming games. It covers both the favorites and the underdogs, offering insights into the factors that could sway the outcomes. Overall, the article serves as a valuable resource for college football fans and bettors, providing a detailed breakdown of the top games in Week 6 and the potential implications for the season.