Politics5/12/2026•CNN

FDA chief to depart after Trump signed off on ousting him | CNN Politics

FDA chief to depart after Trump signed off on ousting him | CNN Politics

Food and Drug Administration Commissioner Marty Makary is leaving the Trump administration, according to three people familiar with the situation, after President Donald Trump signed off on a plan to fire him last week. The FDA chief had come under intense and sustained pressure from within the administration — including over his resistance to approving the sale of flavored e-cigarettes, an episode that prompted Trump to confront him directly — and from outside allies, including in the pharmaceutical industry and anti-abortion interest groups. And he oversaw constant turnover within the agency’s senior ranks. Trump is expected to appoint Kyle Diamantas, a deputy commissioner who heads the agency’s food program, as acting FDA chief, according to two people familiar with the decision. Trump later confirmed that Makary was leaving and that he had tapped Diamantas in a Truth Social post. Still, Makary’s resignation means Trump will now need to fill yet another vacancy — the eventual permanent pick requires Senate confirmation — in the top ranks of the US Health and Human Services Department. The administration already lacks a permanent leader atop the Centers for Disease

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