Health9/7/2025The Guardian

Drug to prevent heart attacks is not ‘better than aspirin’ for everyone | Letters

Drug to prevent heart attacks is not ‘better than aspirin’ for everyone | Letters

The article discusses the limitations of using clopidogrel, a drug proposed to replace aspirin in preventing heart attacks and strokes. It highlights that clopidogrel's effectiveness varies among individuals due to differences in the liver enzyme required for its metabolism. While the drug may be more effective than aspirin for some, for those with lower levels of the enzyme (intermediate or poor metabolizers), aspirin remains the better option. The article emphasizes the need for a personalized approach, as clopidogrel does not work uniformly across all individuals. The key points are that clopidogrel's efficacy is dependent on an individual's genetic makeup, and a one-size-fits-all approach may not be appropriate, with aspirin remaining the better choice for certain individuals.

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