Louisville vs. James Madison prediction, odds: 2025 Week 2 college football Friday picks by expert who's 15-5

Here is a 179-word summary of the news article: SportsLine expert Mike Tierney has released his predictions for the Week 2 college football matchup between James Madison and Louisville on Friday. Tierney has an impressive 15-5 record in his recent college football picks and is sharing his insights on this game. Louisville is favored to win the game, with the Cardinals currently listed as 10.5-point favorites over James Madison. The over/under for the total points scored in the game is set at 62.5. Tierney believes Louisville will be able to cover the spread and win the game convincingly. He cites the Cardinals' strong offense, led by quarterback Malik Cunningham, as a key factor in his prediction. Tierney also points to James Madison's defensive struggles in their season-opening loss as a reason why Louisville will be able to dominate the game. Overall, Tierney is confident in his pick of Louisville to win and cover the spread in this Week 2 matchup.