Gaming3/31/2026•Polygon

20 years later, James Gunn's grossest sci-fi movie is still one of his best

20 years later, James Gunn's grossest sci-fi movie is still one of his best

James Gunn has never shied away from telling stories about outsiders, whether it's anti-heroes of all shapes and sizes in the Marvel Cinematic Universe, or mommy issues for DC. However, while many recognize him for his work in the superhero genre, Gunn began his directing career with the universally panned 2006 horror-comedy film that arrived 20 years ago and grossed pretty much everyone out in the process. Starring Firefly's Nathan Fillion and The Walking Dead's Michael Rooker, Slither is the grossest horror film I've ever seen. While I've often watched horror with my hands over my face, peeking through the slits of my fingers, it's only with Slither that my unwillingness to look comes more from disgust than fear. When a meteorite crashes just outside Wheelsy, a small town in South Carolina, the residents become infected by alien parasites. The first innocent victim of the infection is Grant (Michael Rooker), a wealthy local whose relationship with his wife, Starla (Elizabeth Banks), is on the rocks. However, once infected, Grant becomes a new man. Taken over by the alien parasite, which is essentially a newborn discovering what it means to be human, Grant's new loving side appeal

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