Cowboys vs. Eagles prediction, odds, start time: 2025 NFL Kickoff Game picks, best bets by computer model

The 2025 NFL Kickoff Game will feature a classic NFC East rivalry between the Dallas Cowboys and the Philadelphia Eagles. The game is scheduled for Thursday, September 4, 2025. The SportsLine projection model has analyzed the matchup and made its picks for the game. According to the model, the Cowboys are favored to win the game, with a spread of -3 points. The model also predicts the total points scored in the game will be over 51.5. Key factors in the model's predictions include the strength of the two teams' offenses and defenses, as well as historical trends in the Cowboys-Eagles rivalry. The model has a strong track record of successful predictions in NFL games. Fans and analysts alike will be closely watching this highly anticipated season-opening clash between two of the NFC's top contenders. The game is expected to be a close and hard-fought affair, with both teams vying for an early advantage in the division.