Science10/7/2025NYT

He Was Expected to Get Alzheimer’s 25 Years Ago. Why Hasn’t He?

He Was Expected to Get Alzheimer’s 25 Years Ago. Why Hasn’t He?

The article discusses the case of Doug Whitney, who was expected to develop Alzheimer's disease 25 years ago, but has not yet succumbed to the condition. Scientists are now studying his biology in the hope of finding clues that could lead to new treatments or preventive measures for Alzheimer's. Whitney, now in his 70s, carries a genetic mutation that typically results in early-onset Alzheimer's. However, he has remained cognitively intact, defying expectations. Researchers are conducting extensive tests on Whitney, examining his brain activity, genetic makeup, and other factors, to uncover the mechanisms that have shielded him from the devastating effects of the disease. The article highlights the significance of this case, as understanding the factors that have protected Whitney could provide valuable insights into the development and progression of Alzheimer's. Ultimately, the goal is to leverage these findings to develop more effective strategies for treating or even preventing Alzheimer's in a broader population.

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